A Little More
about myself
BI
This is actually my surname, but I go by this due to Chinese tradition.
In my generation, we skipped the generation character so I only have two characters [*].
Hence, I am referred to as Bi Mian and abbreviated as "Bi"
Bi is pronounced "Bee"
like the insect
MEDICAL CV
Experience
2019 - Present
Cofounder & Lead Investor
Australian Medical Angels
A clinician led angel investing syndicate investing in
Healthtech & Medtech startups in Australia and beyond.
2018 - Present
Managing Director
Regional Specialists Tamworth
Operator of a multi-specialists centre in Tamworth NSW
with over a dozen specialties and 20 different specialists.
2015 - Present
Emergency Medicine Doctor
Multiple hosptials across NSW
Locum across multiple metropolitan, regional and rural EDs
in CMO, registrar and SRMO roles across the years
2013 - 2014
Registrar / SRMO
Sydney Local Health District, Sydney
Multiple surgical and critical care units in Sydney
including General Surgery, Urology, Vascular, ICU
2012
Resident
Alfred Hospital, Melbourne
Trauma unit, Emergency, Neurosurgery and Urology
2011
Intern
Monash Health, Melbourne
Core rotations across Southeastern Melbourne
Psychiatry & Geriatrics
Education
2018
Doctor of Philosophy
University of New South Wales
Doctoral thesis titled: Genetic factors in excitotoxicity and stroke
2012
Postgraduate Diploma of Surgical Anatomy
University of Melbourne
Special focus on head and neck anatomy
2010
MBBS (Honours)
University of Sydney
Central Clinical School – Royal Prince Alfred Hospital
2006
Bachelor of Medical Science
University of Sydney
Majors in Anatomy, Pathology & Neuroscience
ScholarshipS
NHMRC Postgraduate Scholarship
University of New South Wales
The Role of Tau in Stroke
International Merit Scholarship
University of Sydney
Bachelor of Medical Science
RESEARCH CV
EXPERIENCE
2020 - Present
Honorary Research Fellow
Dementia Research Centre
Macquarie University
2014 - 2018
Doctor of Philosophy
Dementia Research Unit
University of New South Wales
2013 - 2014
Affiliate Researcher
Dementia Research Unit
University of New South Wales
2008 - 2010
MBBS Honours Student
Translational Neurodegeneration Laboratory
University of Sydney
2006 - 2008
Part-Time Research Assistant
Alzheimer’s & Parkinson’s Disease Laboratory
University of Sydney
techniques
Molecular Biology
Proficient: PCR, cloning, bacterial transformation, transfection, cell culture, primary culture, sequencing, immunoblotting, Experience: Western blotting, mass spectroscopy, flow cytometry, transcriptome and whole genome sequencing and analysis.
Virology
Proficient: Lentiviral & adeno-associated virus design, production and purification. Utilising viral vectors for genetic manipulation of animals and cell culture.
Histology & Pathology
Proficient: Tissue handling, preparation, immunohistochemisty, standard microscopy, image processing and analysis
Experience: Confocal imaging, batch imaging processing and analysis.
Mouse models
Proficient: Animal husbandry and handling. Small animal micro-surgery. Small animal anaesthesia. Establishing pharmacological and surgical models of disease.
Experience: Behavioural testing. Drug testing.
Data Science
Proficient: Data strategy, exploratory analysis and modelling. Visualisation and communications.
Experience: Machine learning. Shiny
Software: R, RStudio, Google Sheets
GRANTS
MRFF Genomics Health Futures Mission
Prof Beverley Vollenhoven, Dr Vinayak Smith, Dr Rui Wang, Dr Mian Bi, Prof David Coman, Prof David Gardner, Ms Franca Agresta, A/Prof Gavin Sacks, Dr Fabrizzio Horta, Dr Hua Lin
Assessing the clinical impact of pharmacogenomics in IVF using a novel clinical decision support system integrating whole genome sequencing and artificial intelligence (Monash University)
LaunchVic Angel Networks HealthTech
NHMRC Ideas Grant
Dr Ole Tietz, Dr Mian Bi, Prof Katherine Vallis
Intraneuronal immunotherapy to treat Alzheimer’s Disease (Macquarie University)
BIBLIOGRAPHY
2022
Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease
Y Deng, M Bi, F Delerue, SL Forrest, G Chan, J van der Hoven et al.
Acta Neuropathologica 144 (4), 637-650
2021
Syntaxins 6 and 8 facilitate tau into secretory pathways
WS Lee, DCS Tan, Y Deng, A van Hummel, S Ippati, C Stevens et al.
Biochemical Journal 478 (7), 1471-1484
2019
2018
The American Journal of Pathology 188 (6), 1447-1456
The importance of early immunotherapy in patients with faciobrachial dystonic seizures
Brain 141 (2), 348-356
2017
Tau exacerbates excitotoxic brain damage in an animal model of stroke
Nature Communications 8 (1), 1-15
2016
Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice
No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice
Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia
2015
Acta Neuropathologica 130 (5), 661-678
2014
ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke
2012
An unusual presentation of recurrent pneumonia
The Lancet 379 (9811), 192
2011
Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons
2010
Dendritic function of tau mediates amyloid-β toxicity in Alzheimer’s disease mouse models
2009
Phosphorylation of soluble tau differs in Pick’s disease and Alzheimer’s disease brains
2008
Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia